Here, we demonstrate that conolidine, a natural analgesic alkaloid used in common Chinese drugs, targets ACKR3, thus offering additional proof of the correlation concerning ACKR3 and ache modulation and opening alternative therapeutic avenues to the treatment method of Continual pain. We shown that, in distinction to classical opioid receptors, https://whatischronicpain55320.qowap.com/90915478/considerations-to-know-about-what-is-conolidine