The key circulating metabolite of ketamine (norketamine) demonstrated activity at the same receptor with fewer affinity. Norketamine is about one/3 as active as ketamine in lowering halothane needs (MAC) in the rat. Intently watch important indications when ketamine hydrochloride injection and sympathomimetics or vasopressin are co-administered and consider dose adjustment https://ketalinic.com/our-products/